Title: Metformin for Reducing Racial/Ethnic Difference in Prostate Cancer Incidence for Men with Type 2 Diabetes Running title: Metformin for Reducing Prostate Cancer Disparity
نویسندگان
چکیده
Authors: Chen-Pin Wang, Donna M Lehman, Yui-Wing F Lam, John G Kuhn, Devalingam Mahalingam, Steven Weitman, Carlos Lorenzo, John R Downs, Elizabeth A Stuart, Javier Hernandez, Ian M Thompson, Amelie G Ramirez Department of Epidemiology and Biostatistics, University of Texas Health Science Center San Antonio; Department of Cellular and Structural Biology, University of Texas Health Science Center San Antonio; Department of Pharmacology; University of Texas Health Science Center San Antonio; Department of Medicine, University of Texas Health Science Center San Antonio;Department of Pediatrics, University of Texas Health Science Center San Antonio;Department of Biostatistics, Johns Hopkins University;Department of Urology, University of Texas Health Science Center San Antonio.
منابع مشابه
Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer
Objective. To examine the association between metformin use and cancer stage at diagnosis among elderly men with preexisting diabetes mellitus and incident prostate cancer. Methods. This study used a population-based observational cohort of elderly men (≥66 years) with preexisting diabetes and incident prostate cancer between 2008 and 2009 (N = 2,652). Cancer stage at diagnosis (localized versu...
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OBJECTIVE Metformin and statins have shown promise for cancer prevention. This study assessed whether the effect of metformin on prostate cancer (PCa) incidence varied by statin use among type 2 diabetic patients. RESEARCH DESIGN AND METHODS The study cohort consisted of 5,042 type 2 diabetic male patients seen in the Veteran Administration Health Care System who were without prior cancer and...
متن کاملThe Relationship Between Metformin and Serum Prostate‐Specific Antigen Levels
BACKGROUND Metformin is the first-line oral antihyperglycemic of choice for individuals with type 2 diabetes. Recent evidence supports a role for metformin in prostate cancer chemoprotection. However, whether metformin indeed influences prostate biology is unknown. We aimed to study the association between metformin and serum prostate-specific antigen (PSA) levels-the primary prostate cancer bi...
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Prostate cancer (PCa) has become the most frequent type of cancer in men. Recent data suggest that diabetic patients taking metformin have a lower incidence of certain cancer, including PCa. Metformin is the most common drug used in type II diabetes mellitus; its use has been shown to lower the incidence of several cancers, although there are ambiguous data about the anticancer activity of metf...
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Type 2 diabetes mellitus (T2DM) has consistently been associated with decreased risk of prostate cancer; however, if this decrease is related to the use of anti-diabetic drugs is unknown. We prospectively studied men in the comparison cohort in the Prostate Cancer data Base Sweden 3.0, with data on T2DM, use of metformin, sulfonylurea and insulin retrieved from national health care registers an...
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